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8-trimethyl-1
3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
JNJ-55511118 had excellent pharmacokinetic properties and achieved high receptor occupancy following oral administration
Smiles: CN1C(=O)C2C(N=CN2C(=O)CNC2=CC=C(N=N2)C2C=CC=CC=2)N(C)C1=O
InChiKey: DYKHBFJZCIEBJE-UPRLRBBYSA-N
Eltanexor Z-isomer Catalog No.:M20592-C 8-trimethyl-1Eltanexor Z isomer (KPT 8602 Z isomer) is the less active isomer of KPT 8602. KPT 8602 is a potent CRM1 inhibitor. IC50In Vitro: Eltanexor Z isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM 50 M, < 100 nM, > 30 M, respectively. In Vivo: Product information CAS Number: 1642300 78 4 Molecular Weight: 428. 29 Formula: C17H10F6N6O Chemical Name: (2Z) 3 {3 [3,5 bis(trifluoromethyl)phenyl] 1H 1,2,4 triazol 1
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